Endocrine Abstracts

Objectives: Insulin interacts with the GH – insulin-like growth factor (IGF) system by a reciprocal regulation of IGF-binding proteins (IGFBPs) and GH, which in turn interact to regulate insulin sensitivity (IS). We previously showed that IGFBP-2 is involved in the insulin-induced reduction in IGF1 bioactivity. We here address the modulation of IGF1 bioactivity during acute lipid-induced insulin resistance.Methods: 18 healthy men (30.8±2.6 year...

Introduction: The GH/insulin-like growth factor 1 (IGF1) system may modulate the pituitary-gonadal axis in males. Direct pituitary and/or testicular effects might be involved, as well as indirect effects on sex hormone binding globulin (SHBG) and aromatase activity.Methods/design: Nine healthy male volunteers (mean age 37, range 29–49 years) were treated in random order with increasing doses of GH for three weeks (1st week 0.01, 2nd week 0.02, 3rd 0...

Introduction: Observations in patients with GH disturbances and in normal populations have suggested that GH/IGF1 activity could have anti-inflammatory effects. On the other hand, in vitro studies have shown that IGF1 may stimulate the immune system.Methods/design: The study population consisted of 12 healthy volunteers (mean age 36, range 27–49 years) treated with GH for 3 weeks (1st week 0.01 mg/day, 2nd 0.02 mg/day, 3rd 0.03 mg/day) and su...

ObjectiveIt has been suggested that ghrelin may play a role in regulating the growth hormone (GH) response to exercise. This study was designed to determine whether very intense exercise alters circulating ghrelin concentrations. Design: Following Local Ethics Committee approval, 7 male volunteers were familiarised before completing two trials in a random order. In one trial participants performed a single 30-s sprint on a cycle ergometer, in the ...

Aims: To compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart, biphasic insulin aspart 70 (BIAsp70), biphasic insulin aspart 50 (BIAsp50) and soluble human insulin under experimental conditions.Methods: In this randomised, four-period crossover study, 19 type 1 diabetic patients received subcutaneous injections of identical doses (0.2 U/kg) of either insulin aspart, BIAsp70, or BIAsp50 immediately before a standardized meal, or huma...

Introduction: α-Defensins are recently described peptides, which are part of the innate immune system. Increased circulating levels are observed in conditions associated with chronic low grade inflammation, such as ischemic heart disease and in diabetes mellitus (DM). Recently we reported adverse prognostic implications of high α-defensins in patients with type 1 DM. However, it is not clear whether this finding may be generalized to include other groups such as pati...

Objective: The cardiac hormone brain natriuretic peptide (BNP), including the N-terminal fragment of the prohormone (NT-proBNP) have in cross-sectional studies been demonstrated to be inversely associated with BMI. Clearance of these peptides by adipocyt specific receptors have been suggested. We therefore investigated the impact of weight loss on plasma levels of NT-proBNP and adiponectin in obese individuals.Methods: A total of 20 obese women and 2 men...